SYNAPSE: A roadmap to human brain imaging X-ray image reconstruction of part of the connectome of a mouse brain Just published in Physics Reports , SYNAPSE: An international roadmap to large brain imaging , Anton P.J. Stampfl et al. , discusses the challenges, progress, and strategies towards mapping a human brain down to the neuron level with the view of producing a full connectome of the human brain. Challenges are: >1 exabyte of data for one human brain, currently impossible to collect and analyse No present technique can image all neurons and their connections Our solution: Coordinated multi-site use of new radiological techniques and advanced microscopies and spectroscopies For overall connection mapping: microtomography with 0.3 μm resolution in 3 dimensions and imaging at speeds >1 mm 3 /min To obtain detailed mapping in special regions: nanotomography with <10 nm resolution and cryo-electron microscopy with nm resolution For single-molecule mapping: super-re...
